과학기술정보통신부와 한국연구재단이 대한민국 과학기술인상 7월 수상자로 노성훈 서울대 생명과학부 교수를 선정했다. 세포골격을 재생하는 '샤페론 조절인자'의 작동 원리를 규명하여 노화·신경퇴행성 질환 연구의 전기를 마련한 공로를 인정받았다.

노 교수는 기존 세포골격 연구가 '세포의 뼈대'에만 집중했던 한계를 넘어 세포골격의 핵심 단백질인 튜불린을 관리하는 샤페론 단백질에 주목했다. 노 교수는 초저온전자현미경을 활용해 튜불린과 샤페론의 결합 과정을 원자 수준에서 분석해 세포골격이 생성되고 재활용되는 과정을 단계별로 규명했다.

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세포골격은 세포 형태 유지와 물질 수송, 세포 분열에 필수적이지만, 노화와 질병이 진행되면 세포골격이 손상돼 불안정해지고 재생 능력이 저하된다. 세포골격 이상은 신경퇴행성 질환, 암, 근육질환 등과 밀접하게 관련된다. 세포골격이 분자 수준에서 어떻게 형성되고 재생되는지 구체적인 기전이 밝혀지지 않아 생명과학의 난제로 남아 있었다.